2. Prescription Sedatives For more severe cases of anxiety, veterinarians may prescribe pharmacological options like Alprazolam (Xanax), Diazepam (Valium), or Acepromazine. These medications are designed to calm the central nervous system and are typically more potent than natural alternatives. It's important to use these under a vet's guidance, as the correct dosage can vary significantly based on the dog's size, breed, and specific needs.